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カテゴリ:循環器作用薬

11,253 バイト追加、2014年11月25日 (火) 13:49
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== 心臓負荷軽減薬 ==
 
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<table cellspacing="0" cellpadding="0" class="t1">
<tbody>
<tr>
<td valign="middle" class="td1">
<p class="p2"><span class="s1"><b>作用機序</b></span></p>
</td>
<td valign="middle" class="td2">
<p class="p2"><span class="s1"><b>薬物名</b></span></p>
</td>
<td valign="middle" class="td3">
<p class="p2"><span class="s1"><b>適応</b></span></p>
</td>
<td valign="middle" class="td4">
<p class="p2"><span class="s1"><b>　</b></span></p>
</td>
</tr>
<tr>
<td valign="middle" class="td5">
<p class="p3"><span class="s1"><b>α１ﾌﾞﾛｯｶｰ</b></span></p>
</td>
<td valign="top" class="td6">
<p class="p4"><span class="s1">ﾌﾟﾗｿﾞｼﾝ</span></p>
</td>
<td valign="top" class="td7">
<p class="p4"><span class="s1">抗高血圧</span></p>
</td>
<td valign="top" class="td8">
<p class="p5"><br></p>
</td>
</tr>
<tr>
<td valign="middle" class="td9">
<p class="p3"><span class="s1"><b>ACE阻害</b></span></p>
</td>
<td valign="top" class="td10">
<p class="p4"><span class="s1">ｶﾌﾟﾄﾌﾟﾘﾙ</span></p>
</td>
<td valign="top" class="td11">
<p class="p4"><span class="s1">抗高血圧、抗心不全</span></p>
</td>
<td valign="top" class="td12">
<p class="p4"><span class="s1">後負荷↓　ｱﾙﾄﾞｽﾃﾛﾝ分泌抑制により前負荷も↓</span></p>
<p class="p4"><span class="s1">ｱﾝｷﾞｵﾃﾝｼﾝⅡの産生抑制⇒血管拡張</span></p>
</td>
</tr>
<tr>
<td valign="middle" class="td9">
<p class="p3"><span class="s1"><b>利尿薬</b></span></p>
</td>
<td valign="top" class="td10">
<p class="p4"><span class="s1">ﾌﾛｾﾐﾄﾞ</span></p>
<p class="p4"><span class="s1">ﾋﾄﾞﾛｸﾛﾛﾁｱｼﾞﾄﾞ</span></p>
</td>
<td valign="top" class="td11">
<p class="p5"><br></p>
</td>
<td valign="top" class="td12">
<p class="p4"><span class="s1">前負荷↓</span></p>
</td>
</tr>
<tr>
<td rowspan="2" valign="middle" class="td13">
<p class="p3"><span class="s1"><b>Ca２＋ﾁｬﾈﾙﾌﾞﾛｯｶｰ</b></span></p>
<p class="p3"><span class="s1"><b>血管拡張作用</b></span></p>
</td>
<td valign="top" class="td14">
<p class="p4"><span class="s1">ﾆﾌｪｼﾞﾋﾟﾝ</span></p>
</td>
<td rowspan="2" valign="top" class="td15">
<p class="p4"><span class="s1">抗高血圧、抗狭心症</span></p>
</td>
<td rowspan="2" valign="top" class="td16">
<p class="p4"><span class="s1">平滑筋の細胞膜に働いてCa２＋の流入を阻止、血管を拡張させる</span></p>
</td>
</tr>
<tr>
<td valign="top" class="td17">
<p class="p4"><span class="s1">ｼﾞﾙﾁｱｾﾞﾑ</span></p>
</td>
</tr>
<tr>
<td valign="middle" class="td18">
<p class="p3"><span class="s1"><b>細動脈拡張</b></span></p>
</td>
<td valign="top" class="td19">
<p class="p4"><span class="s1">ﾋﾄﾞﾗﾗｼﾞﾝ</span></p>
<p class="p4"><span class="s1">平滑筋に直接作用</span></p>
</td>
<td valign="top" class="td20">
<p class="p4"><span class="s1">抗高血圧</span></p>
</td>
<td valign="top" class="td21">
<p class="p4"><span class="s1">後負荷↓</span></p>
</td>
</tr>
<tr>
<td rowspan="2" valign="middle" class="td22">
<p class="p3"><span class="s1"><b>ｃGMP↑</b></span></p>
<p class="p3"><span class="s1"><b>NOﾄﾞﾅｰ</b></span></p>
</td>
<td valign="top" class="td14">
<p class="p4"><span class="s1">ﾆﾄﾛｸﾞﾘｾﾘﾝ</span></p>
</td>
<td rowspan="2" valign="top" class="td23">
<p class="p4"><span class="s1">抗狭心症、抗心不全</span></p>
</td>
<td rowspan="2" valign="top" class="td24">
<p class="p4"><span class="s1">放出されたNOがｸﾞｱﾆﾙ酸ｼｸﾗｰｾを活性化しｃGMP濃度を高めて血管を拡張させる。動脈拡張だけでなく静脈もよく拡張するので前負荷も軽減される。ﾆﾄﾛｸﾞﾘｾﾘﾝは速効性であり、急性心不全のときに適用。硝酸ｲｿｿﾙﾋﾞﾄﾞは硝酸が薬理有効成分で糖とｴｽﾃﾙにすることによって動態的にすぐれた薬物になっている。</span></p>
</td>
</tr>
<tr>
<td valign="top" class="td25">
<p class="p4"><span class="s1">硝酸ｲｿｿﾙﾋﾞﾄﾞ</span></p>
</td>
</tr>
</tbody>
</table>
<p class="p5"><br></p>
</body>
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